## Abstract An efficient small scale synthesis of ^14^C labeled 1‐vinyl‐2‐pyrrolidinone (NVP) is described. The cyclization of commercially available [1,2,3,4‐^14^C]‐γ‐aminobutyric acid (GABA) gives [2,3,4,5‐^14^C]‐2‐pyrrolidinone which is vinylized with vinyl acetate via a sodium tetrachloropallad
Synthesis of 2-pyrrolidinone-5-14C
✍ Scribed by A. J. Villani; W. L. Mendelson; D. W. Blackburn
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- French
- Weight
- 197 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A convenient synthesis of the pharmacological intermediate 2‐pyrrolidione‐5‐^14^C, was developed using potassium cyanide ^14^C as starting material. Potassim cyanide‐^14^C was converted to 2‐pyrrolidinone‐5‐^14^C in an overall 56% radiochemical yield.
📜 SIMILAR VOLUMES
## Abstract Diethyl ethoxymethylenemalonate was condensed with thiourea−^14^C in the presence of sodium ethylate to give ethyl 2‐thio‐6‐oxypyrimidine‐5‐carboxylate‐2−^14^C. Desulfurization of the latter pyrimidine with chloroacetic acid gave uracil‐5‐carboxylic acid‐2−^14^C, which was subsequently
therefore been incorporated in this isoprenoid. The
[2‐^14^ C]2,5‐dichloropyrimidine is a useful reagent for labeling biologically active compounds for use in hepatocyte transport studies, protein covalent binding, and metabolic profiling. This paper describes a novel five‐step synthesis of [2‐^14^ C]2,5‐dichloropyrimidine from readily available [^14