𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 2-pyrrolidinone-5-14C

✍ Scribed by A. J. Villani; W. L. Mendelson; D. W. Blackburn


Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
197 KB
Volume
9
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

A convenient synthesis of the pharmacological intermediate 2‐pyrrolidione‐5‐^14^C, was developed using potassium cyanide ^14^C as starting material. Potassim cyanide‐^14^C was converted to 2‐pyrrolidinone‐5‐^14^C in an overall 56% radiochemical yield.


📜 SIMILAR VOLUMES


Synthesis of [2,3,4,5-14C]-1-vinyl-2-pyr
✍ George A. Digenis; J. S. McClanahan; Pei-Lin Chen 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 257 KB 👁 1 views

## Abstract An efficient small scale synthesis of ^14^C labeled 1‐vinyl‐2‐pyrrolidinone (NVP) is described. The cyclization of commercially available [1,2,3,4‐^14^C]‐γ‐aminobutyric acid (GABA) gives [2,3,4,5‐^14^C]‐2‐pyrrolidinone which is vinylized with vinyl acetate via a sodium tetrachloropallad

Synthesis of 5-trifluoromethyluracil-2−1
✍ Arthur J. Zambito; Earl M. Chamberlin 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 234 KB

## Abstract Diethyl ethoxymethylenemalonate was condensed with thiourea−^14^C in the presence of sodium ethylate to give ethyl 2‐thio‐6‐oxypyrimidine‐5‐carboxylate‐2−^14^C. Desulfurization of the latter pyrimidine with chloroacetic acid gave uracil‐5‐carboxylic acid‐2−^14^C, which was subsequently

A novel synthesis of [2-14C]2,5-dichloro
✍ Scott B. Tran; Brad D. Maxwell; Hong Wu; Samuel J. Bonacorsi Jr. 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 182 KB

[2‐^14^ C]2,5‐dichloropyrimidine is a useful reagent for labeling biologically active compounds for use in hepatocyte transport studies, protein covalent binding, and metabolic profiling. This paper describes a novel five‐step synthesis of [2‐^14^ C]2,5‐dichloropyrimidine from readily available [^14