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Synthesis of [2,3,4,5-14C]-1-vinyl-2-pyrrolidinone

✍ Scribed by George A. Digenis; J. S. McClanahan; Pei-Lin Chen

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 257 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330103

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✦ Synopsis

Abstract

An efficient small scale synthesis of ^14^C labeled 1‐vinyl‐2‐pyrrolidinone (NVP) is described. The cyclization of commercially available [1,2,3,4‐^14^C]‐γ‐aminobutyric acid (GABA) gives [2,3,4,5‐^14^C]‐2‐pyrrolidinone which is vinylized with vinyl acetate via a sodium tetrachloropalladate catalyst to give good yields of [2,3,4,5‐^14^C]‐1‐vinyl‐2‐pyrrolidinone.

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