✦ LIBER ✦

Synthesis of mycophenolate mofetil-[14C], RS-61443-14C

✍ Scribed by Glenn T. Huang; Howard Parnes

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 384 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360508

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✦ Synopsis

Synthesis of the potent immunosuppressive agent, mycophenolate mofetil (I) labelled with carbon-14 is described. Methoxyethoxymethyl (MEM) protected mycophenolate norbromide (2) was prepared from unlabelled mycophenolic acid (2) using a modified Hunsdiecker reaction. A three step synthesis furnished the title compound, having a specific activity of 53.8 mCi/mmol, in 49.5% overall yield from K14CN.

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