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Synthesis of [14C]-labelled dihydropyridine calcium channel entry blockers: Nicardipine-[4-14C] and RS-93522-[4-14C]

✍ Scribed by Howard Parnes; Glenn T. Huang; Emma J. Shelton

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
376 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The Hantzsch synthesis has been applied to the general prepararion of 4-aryl-dihydropyridines labelled in the metabolically stable 4-position of the dihydropyridine ring. The synthesis is based on the preparation of a key common intermediate, m-nirr~benzaldehyde-[formyl-~~C], in high yield from Ba14C03.

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