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Synthesis of 14C-labeled antitumor agents. I. Synthesis of the ring- and side-chain-14C-labeled DL-4,4′-propylenedi-2,6-piperazinediones

✍ Scribed by Ying-Tsung Lin; M. A. Leaffer; Masato Tanabe

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
415 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The ring‐ and side‐chain‐^14^C‐labeled DL‐4,4′‐propylenedi‐2,6‐piperazinediones (I) were synthesized from chloroacetic acid‐1‐^14^C in two steps and from DL‐analine‐1‐^14^C in six steps, respectively. The radiochemical yield for the ring labeling was 24.5%; for the side‐chain labeling it was 13.7%. In the side‐chain labeling, the synthesis involved a new method for preparing DL‐proprylenediamine from DL‐alaninamide.

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