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Synthesis of the antiinflammatory prodrug RS-42169-14C

✍ Scribed by Howard Parnes; Glenn T. Huang

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 281 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360106

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✦ Synopsis

A facile synthesis of the antiinflammatory agent RS-42169-14C, based on a carbonation/cycloaddition sequence is described. The product was obtained in 36% yield from Ba14CO3 at a specific activity of 52 mCilmmole. The design of the six step sequence was such that pure intermediates were isolated by extractive workup, and only a single chromatographic purification was required.

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