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Synthesis of 14C isotopic isomers of tenidap—A novel antiinflammatory agent

✍ Scribed by Frank W. Rusek; Fred C. Falkner; Diane L. Johnson; Ralph P. Robinson; Lawrence S. Melvin Jr.

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
339 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

Two isotopic isomers of tenidap, a novel antiinflammatory agent, were prepared. Compound 6 (specific activity = 10.24 rnCi/rnmol), having 1% in the indole ring, was prepared in three steps (52% overall yield) starting from 1 H-[14C]indole-2,3-dione. Compound 11 (specific activity = 57.1 6 mCi/mmol, radiochemical purity = 99.0%), with 14C in the C-3 rnethylene, was prepared in two steps (66% overall yield) beginning with 2-thiophenecarb~xylic-[~~C-carbonyl] acid.

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