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A novel synthesis of fumaric acid-1-14C

✍ Scribed by Herman Rutner; Raul Rapun

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
227 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A simple, two‐step synthesis of fumaric acid‐1‐^14^C from radioactive potassium cyanide and methyl 2‐chloroacrylate is described. The intermediate products, methyl cis and trans 3‐cyanoacrylates and the cis and trans 3‐cyanoacrylic acids, were hydrolyzed directly to fumaric acid‐1‐^14^C in 55‐60% yields. D, L‐malic acid‐COOH‐^14^C was also obtained as a byproduct in 9% yield. A reaction mechanism is proposed.

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