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Synthesis of [1-14C-carboxy]-4-benzoylbenzoic acid

✍ Scribed by Kay L. Nakamaye; Ralph G. Yount

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
266 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

1-14C-Ca oxy]-4-benzoylbenzoic acid has been prepared v i a a Grignard r e a c t i o n w i t h %Oz.

4-Bromobenzophenone was converted t o (4-braopheny1)phenyldichloranethane using phosphorus pentachloride. was reacted w i t h methoxide i o n t o form 4-bromobenzophenone dimethyl k e t a l which was subsequently converted t o i t s Gsignard reagent, carboxylated with 14CO2, and acid hydrolyzed t o t h e f i n a l product. reagent, v i r t u a l l y q u a n t i t a t i v e conversion of 14C02 t o product was obtained.

The d i c h l o r o canpound

Using excess Grignard

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