1-14C-Ca oxy]-4-benzoylbenzoic acid has been prepared v i a a Grignard r e a c t i o n w i t h %Oz. 4-Bromobenzophenone was converted t o (4-braopheny1)phenyldichloranethane using phosphorus pentachloride. was reacted w i t h methoxide i o n t o form 4-bromobenzophenone dimethyl k e t a l which was
Synthesis of [carbonyl-14C]-4-benzoylbenzoic acid, a photolabelling reagent
✍ Scribed by J-M. Gomis; J. Santolini; F. André; J-P. Noel
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 200 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
## Abstract A two‐step synthesis of the title compound from [__cyano__‐^14^C]‐copper(I) cyanide is described. The method is extensible to the preparation of carbonyl‐labelled 3,4‐dihydroxybenzaldehyde.
## Abstract The synthesis of 3‐[ 2′,4′,5′‐triethoxybenzoyl‐(carbonyl‐^14^C)]‐propionic acid (VII) is described. Chloroacetonitrile‐^14^C (IV) was prepared from chloroacetic‐1‐^14^C acid (I) according to the well‐known procedure. IV was reacted with 1,2,4‐triethoxybenzene in the presence of ZnCl~2~
## Abstract The synthesis of the N‐(4‐iodo‐2,6‐diethylphenylcarbamoylmethyl) iminodiacetic acid labelled with ^14^C at the carbonyl carbon atom which was required for metabolism studies is described. The complex formation between the title product and Tc‐99m is also presented.
## Abstract A simple and convenient method for the condensation of paminophenol (I) with ^14^C‐acetic anhydride (II) yields up to 76% of ^14^C‐labelled 4‐hydroxyphenylacetamide (carbonyl‐^14^C) (III). Typical synthesis time is 60 minutes. Radioactive yield is 51%, and specific activity is 0.22 μCi/