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Synthesis of carboxy-14C furosemide

✍ Scribed by A. A. Liebman; A. M. Dorsky; D. H. Malarek

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
211 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A modification of the Sandmeyer reaction which requires only a moderate excess of cyanide‐^14^C was utilized for the preparation of 4‐chloro‐2‐fluorobenzonitrile‐7‐^14^C (3). After hydrolysis, the resulting acid (4) was converted to carboxy labelled furosemide (6) by existing methods. This procedure is potentially useful for insertion of ^14^C in compounds that fail to undergo conventional carbonation reactions.

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