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Synthesis of 1-carboxy-N, N, N-tri-[methyl-14C] methanaminium chloride (betaine [methyl-14C] hydrochloride)

✍ Scribed by S. Goszczynski; R.L. Crawford

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 194 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199606)38:6<591::aid-jlcr864>3.0.co;2-e

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✦ Synopsis

Methyl bromoacetate was reacted with trimethyla~nine-[~'C] dissolved in methanol, forming the methyl ester of [I4C] labeled betaine hydrobromide. The methyl ester was hydrolyzed in an alkaline medium to (carboxymethy1)trimethylammonium hydroxide inner salt, and then transformed into the hydrochloride by treatment with an equivalent amount of hydrochloric acid, yielding high purity material with a specific activity of 19.2 pCi/mmol and overall yield of 81.7%.

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