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Synthesis of [γ-14C]-γ-oxo-2-dibenzofuranbutanoic acid (furobufen) and 2-dibenzofuranacetic[carboxy-14C] acid

✍ Scribed by E. S. Ferdinandi

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
339 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The syntheses of [γ‐^14^C]‐γ‐oxo‐2‐dibenzofuranbutanoic acid (furobufen) 7 and 2‐dibenzofuranacetic[carboxy‐^14^C] acid 3b, a major metabolite of furobufen, are described. A by‐product, the dialkylated malonate 6 obtained in the synthesis of 7, was isolated and characterized.

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