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Synthesis of trans-[13,14-14C2]-retinoic acid

✍ Scribed by Heinz Kaegi; Edward Chew; Ping-Lu Chien

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
248 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Trans‐[13,14‐^14^C~2~]‐Retinoic acid has been synthesized by condensation of β‐ionylideneacetaldehyde and ^14^C‐labeled methyl senecioate in the presence of potassium amide in ether. A convenient synthesis of the key intermediate, methyl (diethoxyphosphinyl)‐[2‐^14^C]acetate, is also described.

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