𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of methyl trans-(10- 14C)-retinoate and trans-(10- 14C)-retinol

✍ Scribed by J. D. Bu'Lock; S. A. Quarrie; D. A. Taylor

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
353 KB
Volume
9
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The preparation of the title compunds, using β‐ionone, is accomplished in fair overall radiochemical yield from (2‐^14^C) bromacetic acid, in 7 and 8 steps respectively. The sequence utilises ylid reactions of the phosphonoacetate derived from bromacetic ester, and is also capable of the introduction of label at C‐14.

📜 SIMILAR VOLUMES

Synthesis of trans-[13,14-14C2]-retinoic
Synthesis of trans-[13,14-14C2]-retinoic acid
✍ Heinz Kaegi; Edward Chew; Ping-Lu Chien 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 248 KB

## Abstract Trans‐[13,14‐^14^C~2~]‐Retinoic acid has been synthesized by condensation of β‐ionylideneacetaldehyde and ^14^C‐labeled methyl senecioate in the presence of potassium amide in ether. A convenient synthesis of the key intermediate, methyl (diethoxyphosphinyl)‐[2‐^14^C]acetate, is also de

Synthesis of all trans [3′-14C]menaquino
Synthesis of all trans [3′-14C]menaquinone-4
✍ K. Shimada; K. Tadano; T. Satoh; K. Hashimoto; S. Tanaka; T. Yuzuriha 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB

A synthetic procedure for producing all trans [3A4C]menaquinone-4 is described The radiolabe is introduced using ethyl [3-'4C]acetoacetate as shown in the scheme. The final product has high chemical and radiochemical purity with a specific activity of 669 MBS/mnol. The overall radiochemical yield is

Synthesis of 7-amino-9a-methoxy-10-[14C]
Synthesis of 7-amino-9a-methoxy-10-[14C]carbamoyl mitosane (10-[14C]carbamoyl mitomycin C)
✍ U. J. Haynes; J. E. Swigor; T. Kaneko 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 155 KB

## Abstract The synthesis of the title compound (5) is described. Treatment of mitomycin C with sodium methoxide gave decarbamoyl mitomycin C (2). Reaction with acetic anhydride in methanol yielded N1a‐acetyl‐mitomycin C (3). Treatment with [^14^C]phosgene in the presence of N,N‐dimethylaniline yie

The synthesis and purification of pentyl
The synthesis and purification of pentylenetetrazole-10-14C
✍ J. F. Stiver; J. B. Data; J. E. Christian 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 French ⚖ 239 KB

## Abstract Pentylenetrazole‐10‐^14^C was synthesized by reacting hydrazoic acid with cyclohexanone‐1‐^14^C. Purification was carried out using sublimation and thick layer chromatography. Proof of radiochemical purity was determined using thin layer chromatography and autoradiography. The specific