𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 7-amino-9a-methoxy-10-[14C]carbamoyl mitosane (10-[14C]carbamoyl mitomycin C)

✍ Scribed by U. J. Haynes; J. E. Swigor; T. Kaneko

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
155 KB
Volume
28
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of the title compound (5) is described. Treatment of mitomycin C with sodium methoxide gave decarbamoyl mitomycin C (2). Reaction with acetic anhydride in methanol yielded N1a‐acetyl‐mitomycin C (3). Treatment with [^14^C]phosgene in the presence of N,N‐dimethylaniline yielded [^14^C]chloroformate (4). Conversion of the chloroformate to the carbamate and removal of the protecting group with excess ammonia produced the title compound (5).

📜 SIMILAR VOLUMES

Synthesis of 3-(4-carbamoylpyridiniometh
Synthesis of 3-(4-carbamoylpyridiniomethyl)-7B-(2-sulfophenyl-acetamido)-ceph-3-em-carboxylate monosodium salt labelled at [14C]carbamoyl and [1-14C]acetamido groups
✍ Nobuyoshi Hayashi; Tadashi Toga; Norio Tada; Toshiyuki Azuma 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 218 KB 👁 1 views

## OC-Sulfobenzylpenicillin as a new semi-synthetic penicillin having a broad antibiotic spectrum against Gram-positive and negative bacteria was first prepared in these laboratories and has already been supplied to clinical use. Moreover, many semisynthetic penicillins and cephalosporins have bee

A facile micromolar reduction of [1,2,3,
A facile micromolar reduction of [1,2,3,4,10-14C]aldrin to 6,7-dihydro[1,2,3,4 10-14C]aldrin
✍ Neil J. Lewis; Frederick D. Cazer 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB 👁 1 views

## Abstract The preparation of 6,7‐dihydro[1,2,3,4,10‐^14^C]aldrin is reported by catalytic reduction of [1,2,3,4,10‐^14^C]aldrin. Modification of previously published conditions afforded the desired product in 97.1% yield as assayed by electron capture gas chromatography. The convenient one vessel

Labeled metabolites of polycyclic aromat
Labeled metabolites of polycyclic aromatic hydrocarbons. V. trans-7,8-dihydrobenzo[a]pyrene-7,8-diol-7-14C and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-7-14C
✍ Daniel J. McCaustland; W. P. Duncan; James F. Engel 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

## Abstract trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐7‐^14^C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]‐pyrene‐7‐^14^C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K^14^CN as the labeled precursor. The overall radio

Synthesis of Carbon-14 labeled gadoterid
Synthesis of Carbon-14 labeled gadoteridol, [1,4,7-Tris(carboxymethyl)-10-(2-hydroxy-1-[14C]propyl)-1,4,7,10-tetraazacyclododecanato]gadolinium
✍ D. D. Dischino; J. E. Swigor 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 207 KB

## Abstract Carbon‐14 labeled Gadoteridol, [1,4,7‐Tris(carboxymethyl)‐10‐(2‐hydroxy‐1‐[^14^C]propyl)‐1,4,7,10‐tetraazacyclododecanato]gadolinium, was prepared from 1‐[^14^C] propylene oxide in a total yield of 30.4% and a radiochemical purity of 99.2%.

Synthesis of [14C]-labelled 3-[N-(4-brom
Synthesis of [14C]-labelled 3-[N-(4-bromophenyl)carbamoyl]-7-chloro-4-hydroxycoumarin and 3-[N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]-7-chloro-4-hydroxycoumarin
✍ Byung H. Lee; Michael F. Clothier 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 196 KB 👁 1 views

## Abstract The novel [^14^C]‐labelled 3‐carbamoyl‐4‐hydroxycoumarins were prepared in two steps from 4‐chloro‐acetylsalicyloyl chloride (3). The isotope was incorporated by the reaction of diethyl malonate‐1,3‐^14^C with 4‐chloro‐acetylsalicyloyl chloride (3). Subsequent condensation of the result