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Synthesis of homovanillic acid-2−14C, homoprotocatechuic acid-2−14C, 3′, 4′-dihydroxymandelic acid-2−14C and 1-(4 hydroxy-3-methoxyphenyl)-ethylene glycol-1−14C

✍ Scribed by A. A. Liebman; D. H. Malarek; A. M. Dorsky; H. H. Kaegi

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
493 KB
Volume
7
Category
Article
ISSN
0022-2135

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✦ Synopsis

Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the corresponding phenylacetonitriles via the intermediate chlorides and to the cyanohydrins via the intermediate aldehydes in yields signifcantly higher than previously reported. Overall radiochemical yields of the title compounds were in the order of 25 from I4CO, and specijic activities ranged from 4-10 mClmmole. The collated procedures have general applicability.

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