## Abstract A general method for microscale synthesis of ^14^C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐
Synthesis of 3-indolyl(1-14C)acetic, 3-indolyl(2-14C) acetic and 3-indolyl(1,2-14C2)acetic acids
✍ Scribed by K. V. Viswanathan; T. V. Ramaamurthy
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 208 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The synthesis of 3‐indolylacetic acid labelled with ^14^C in side chain carbon atoms has been effected using (1‐^14^C)glycolic acid, (1,2‐^14^C~2~)glycolic acid and (2‐^14^C)glycolic acid in an yield of 40‐60%. Some of the parameters that affect the synthesis have been studied and the results are reported in this paper.
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Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co
## Abstract N‐(2‐Piperidylmethyl)‐2,5‐bis(2,2,2‐trifluoroethoxy)benzamide acetate (flecainide acetate; R‐818), a new antiarrhythmic agent, was labelled with carbon‐14 at the carboxamide position for metabolic studies. A three‐step synthetic route starting from 2,5‐dihydroxybenzoic acid‐carboxyl‐^14
## Abstract 3‐Indolylacetic acid (IAA) is the major auxin in higher plants and plays a key role in plant growth and development. We report the rapid radiolabeling of the important plant hormone using carbon‐11 (half life: 20.4 min) enabling __in vivo__ imaging of its distribution and movement in wh
## Abstract The synthesis of 1,1,3,3‐tetraethoxypropane‐1,2,3‐^14^C~3~ from uniformly labeled paraldehyde is described. The synthesis involves three steps and proceeds in an overall yield of 25%. The final product is greater than 95% radiochemically pure and it is stable indefinitely when stored as