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Synthesis of 14C-labeled halogen substituted indole-3-acetic acids

✍ Scribed by Bruce G. Baldi; Janet Pernise Slovin; Jerry D. Cohen

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
254 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A general method for microscale synthesis of ^14^C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐Chlorophenyl‐hydrazine yielded a mixture of the 4 and 6 chloro compounds that was resolved by C~18~‐reverse phase high performance liquid chromatography.

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