Preparation of radioactively labelled indole-3-acetic acid precursors
✍ Scribed by Frieder Hofmann; Thomas Rausch; Prof. Dr. Willy Hilgenberg
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 162 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A microscale method for the synthesis of indole‐3‐acetaldehyde, indole‐3‐ethanol, indole‐3‐acetaldoxime and indole‐3‐acetonitrile from radioactively labelled tryptophan with high yield and no reduction in specific radioactivity is described.
📜 SIMILAR VOLUMES
## Abstract A general method for microscale synthesis of ^14^C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐
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## Abstract The synthesis of indole‐3‐acetyl‐2‐^14^C‐N‐aspartic acid from carrier‐free indole‐3‐acetic acid‐2‐^14^C (54.5 mCi/mmole) and bis‐t‐butyl‐l‐aspartic acid was accomplished by coupling with dicyclohexylcarbodiimide followed by removal of the ester blocking groups by treatment with 2 N NaOH