𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of ring 14C-methyl labeled retinyl acetate

✍ Scribed by William T. Colwell; Caroline Soohoo; Joseph I. Degraw

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
267 KB
Volume
16
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A method for incorporation of a ^14^C‐label in the ring geminal methyl moiety of Vitamin A is described. The procedure involves mono methylation of 2,6‐dimethylcyclohexanone with ^14^C‐methyl iodide as catalyzed by potassium hydride to afford 2‐^14^C, 2,6‐trimethylcyclohexanone. Subsequent condensation with an 11‐carbon acetylenic side chain, followed by reduction, acetylation and dehydration yielded ^14^C‐retinyl acetate. Final purification was achieved by preparative thin layer chromatography.

📜 SIMILAR VOLUMES

A high yield synthesis of C-14-ring-labe
A high yield synthesis of C-14-ring-labeled and C-14-methyl-labeled N-methyl-N-nitrosoaniline
✍ C. J. Grandjean 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 232 KB 👁 1 views

## Abstract A synthetic procedure for C‐14‐labeled N‐methyl‐N‐nitrosoaniline is presented. Separate labeling of the methyl and phenyl side chains was achieved by using C‐14‐labeled methyl iodide and aniline, respectively. The overall yield of the four reactions was 62% and the final products were s

Synthesis of C-14 labelled methyl stercu
Synthesis of C-14 labelled methyl sterculate
✍ Norman E. Pawlowski; Joseph E. Nixon; Donald J. Lee; Russell O. Sinnhuber 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 164 KB 👁 1 views

## Abstract Methyl sterculate, a cyclopropenoid fatty acid, has been synthesized with carbon‐14 as the methylene carbon in the cyclopropene ring.

Synthesis of specific labelled [methyl-1
Synthesis of specific labelled [methyl-14C]sarin
✍ A. Chang Sin-Ren; Gaetano Riggio; Wolfgang H. Hopff; Peter G. Waser 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 384 KB

Synthesis o f specific labelled [methyl-14Clsarin. The synthesis of label led [methyl-14Clsarin, [14Clmethylphosphonofluoridic acid 1-methylethyl ester, was accomplished by another approach as for nonlabelled sarin in a tele-conducted reaction vessel. The purity was estimated by IR, GC, and GC-MS a

Synthesis of 14C-labelled antitumor agen
Synthesis of 14C-labelled antitumor agents. II. A facile synthesis of ring-14C-labelled para-toluic acid as an intermediate for synthesis of ring-14C-labelled procarbazine
✍ Ying-Tsung Lin; Robert J. Dummel; Morris A. Leaffer; Masato Tanabe 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 156 KB 👁 1 views

## Abstract p‐Toluic acid‐ring‐^14^C was synthesized by the Friedel‐Crafts p‐carbamylation of toluene‐ring‐^14^C with N,N‐disubstituted carbamyl chloride and subsequent hydrolysis. The radiochemical yield was 61%. An attempt was made to apply this method for the synthesis of benzoic acid‐ring‐^14^C