## Abstract Synthetic routes for the synthesis of [^14^C] sarin and related nerve agents are described. Triethyl phosphite and [^14^C] methyl iodide are reacted in the Michaelis–Arbusov reaction to produce diethyl methyl phosphonate which is converted to methylphosphonic acid by hydrolysis. After c
Synthesis of specific labelled [methyl-14C]sarin
✍ Scribed by A. Chang Sin-Ren; Gaetano Riggio; Wolfgang H. Hopff; Peter G. Waser
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 384 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Synthesis o f specific labelled [methyl-14Clsarin.
The synthesis of label led [methyl-14Clsarin, [14Clmethylphosphonofluoridic acid 1-methylethyl ester, was accomplished by another approach as for nonlabelled sarin in a tele-conducted reaction vessel. The purity was estimated by IR, GC, and GC-MS and the stability in different media was examined.
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## Abstract A method for incorporation of a ^14^C‐label in the ring geminal methyl moiety of Vitamin A is described. The procedure involves mono methylation of 2,6‐dimethylcyclohexanone with ^14^C‐methyl iodide as catalyzed by potassium hydride to afford 2‐^14^C, 2,6‐trimethylcyclohexanone. Subsequ
Three major DDD isomers, O,P'-DDD, m,p'-DDD and p,p'-DDD, 14C-labelled in the para-chlorophenyl ring, have been synthesized. The DDD products were obtained in isotopic yields ranging fran 42% to 58% and were of high specific activities; 31 mCi/mmol (0,~'-DDD; m,p'-DDD) and 19,8 mCi/mmol (p,p'-DDD).