The synthesis of and 3H labelled methylazoxymethylacetate, ( M A M -OAc) , a hepatotoxic and carcinogenic compound, was accomplished by the incorporation of a radioisotope labelled methyl group into N, N'-dimethylhydrazine with methyl iodide instead oj dimethyl sulfate. Monosodium dibenzoylhydrazine
Synthesis of 14C-labelled methylazoxymethanol acetate of high specific activity
โ Scribed by Frederick D. Cazer; Satish B. Barnela; Kultar S. Kumar; Prabhakar L. Kamat; George E. Milo; Donald T. Witiak
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 285 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Three major DDD isomers, O,P'-DDD, m,p'-DDD and p,p'-DDD, 14C-labelled in the para-chlorophenyl ring, have been synthesized. The DDD products were obtained in isotopic yields ranging fran 42% to 58% and were of high specific activities; 31 mCi/mmol (0,~'-DDD; m,p'-DDD) and 19,8 mCi/mmol (p,p'-DDD).
The tobacco smoke p a r t i c u l a t e phase marker d o t r i a c o n t a n e was l a b e l l e d w i t h tritium a t p o s i t i o n s 15, 16, 1 7 and 18 by t h e c a t a l y t i c r e d u c t i o n of dotriaconta-15, 17-diyne. This was obtained by o x i d a t i v e l y coupling hexadec-1-yne, i n
Synthesis o f specific labelled [methyl-14Clsarin. The synthesis of label led [methyl-14Clsarin, [14Clmethylphosphonofluoridic acid 1-methylethyl ester, was accomplished by another approach as for nonlabelled sarin in a tele-conducted reaction vessel. The purity was estimated by IR, GC, and GC-MS a
Tritium labelled 8-chloro-l-[(dimethylamino)methyl]-6-phenyl-4H-striazolo[4,3-a][ 1,4]benzodiazepine was prepared from [3Hlbromomethane and 8chloro-I -[(N-methylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][ 1.4lbenzodiazepine. The latter compound was efficiently obtained from 8-chloro-6-phenyl- 4H-s-