✦ LIBER ✦

Synthesis of tritium labelled adinazolam with high specific activity

✍ Scribed by John R. Palmer

Publisher: John Wiley and Sons
Year: 1986
Tongue: French
Weight: 246 KB
Volume: 23
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580230206

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✦ Synopsis

Tritium labelled 8-chloro-l-[(dimethylamino)methyl]-6-phenyl-4H-striazolo[4,3-a][ 1,4]benzodiazepine was prepared from [3Hlbromomethane and 8chloro-I -[(N-methylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][ 1.4lbenzodiazepine. The latter compound was efficiently obtained from 8-chloro-6-phenyl- 4H-s-triazol0[4,3-a][1,4]bentodiazepine by hydroxymethylation, mesylation and mesylate displacement with aqueous methylamine. The titled product had a specific activity of 80 Ci/mmole.

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