𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The synthesis of betaxolol labelled with tritium at high specific activity

✍ Scribed by John Allen; André Tizot

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
204 KB
Volume
25
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Department of Chemistry Labelled Compounds and Metabolite Synthesis Group

31, avenue Paul Vaillant-Couturier 92220 BAGNEUX (FRANCE) SmOuRY The synthesis of betaxolol, a new 8-blocking agent. labelled with tritium in high specific activity ('19 Ci/mmol) is described. The tritium was incorporated into the molecule via a catalytic reductive debromination of the 2.6-dibromobetaxolol precursor in the presence of tritium gas. This labelled compound has been used in receptor binding studies and also in studying the release of betaxolol from rat atrial slices on electrical stimulation.

📜 SIMILAR VOLUMES

Synthesis of tritium labelled adinazolam
Synthesis of tritium labelled adinazolam with high specific activity
✍ John R. Palmer 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 246 KB

Tritium labelled 8-chloro-l-[(dimethylamino)methyl]-6-phenyl-4H-striazolo[4,3-a][ 1,4]benzodiazepine was prepared from [3Hlbromomethane and 8chloro-I -[(N-methylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][ 1.4lbenzodiazepine. The latter compound was efficiently obtained from 8-chloro-6-phenyl- 4H-s-

Synthesis of high specific activity trit
Synthesis of high specific activity tritium-labelled dotriacontane
✍ T. H. Houseman; S. H. Binns; K. Phillips 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 198 KB 👁 1 views

The tobacco smoke p a r t i c u l a t e phase marker d o t r i a c o n t a n e was l a b e l l e d w i t h tritium a t p o s i t i o n s 15, 16, 1 7 and 18 by t h e c a t a l y t i c r e d u c t i o n of dotriaconta-15, 17-diyne. This was obtained by o x i d a t i v e l y coupling hexadec-1-yne, i n

Synthesis of tritium labeled veratridine
Synthesis of tritium labeled veratridine with high specific activity
✍ Hem L. Tripathi; Gregory A. Yost 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 214 KB

Synthesis of v e r a t r i d i n e labeled with tritium on t h e aromatic residue a t p o s i t i o n 5' i s described. F i r s t , a precursor bromoveratridine, 3-(5-bromoveratroyl) veracevine, was prepared which was converted i n t o t h e labeled v e r a t r i d i n e by cata l y t i c dehalogena

Synthesis of tritium-labelled imipramine
Synthesis of tritium-labelled imipramine and desipramine with high specific activities
✍ L. A. Yakovleva; Ju. L. Kaminski; L. P. Sosnova; B. K. Kudelin 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 189 KB

## Abstract [G‐^3^H]imipramine and [G‐^3^H]desipramine with specific activities 110–160 and 80–100 kCi/mol, respectively were synthesized by high temperature solid‐phase catalytic isotope exchange with gaseous tritium.

The preparation and stability of DL-α-to
The preparation and stability of DL-α-tocopherol labelled with tritium at high specific activity
✍ E. A. Evans; R. F. Phillips 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 French ⚖ 389 KB

Hydrogen-tritium exchange labelling methods proved to be unsatisfactory for the preparation of tritiated DL-a-tocopherol at high specific activity. The preparation of a-tocopherol specijcally labelled in the 5-methyl hydrogen positions is described : the method permits specific activities in the cur