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The preparation and stability of DL-α-tocopherol labelled with tritium at high specific activity

✍ Scribed by E. A. Evans; R. F. Phillips

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
389 KB
Volume
5
Category
Article
ISSN
0022-2135

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✦ Synopsis

Hydrogen-tritium exchange labelling methods proved to be unsatisfactory for the preparation of tritiated DL-a-tocopherol at high specific activity. The preparation of a-tocopherol specijcally labelled in the 5-methyl hydrogen positions is described : the method permits specific activities in the curies per millimole range to be readily achieved. The synthesis is also suitable jor preparing tocopherol doubly labelled with tritium and carbon-14. The stability of the tritiated vitamin on storage is discussed.

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