Since its introduction to medicine several years ago, diphenylhydantoin (DPH) has been widely used in the treatment of epilespy, both in adults and children.( 2) The effects of the drug is well correlated with the plasma levels. high levels have adverse effects. ( 3 )
A method for the preparation of tritium labelled hydrocarbons of high specific activity
โ Scribed by G. Ayrey; J. M. Lynch
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- French
- Weight
- 221 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Tritiated hydrocarbons may be prepared by Kolbe electrolysis of carboxylic acids which have been labelled by catalytic exchange in tritiated water.
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The tobacco smoke p a r t i c u l a t e phase marker d o t r i a c o n t a n e was l a b e l l e d w i t h tritium a t p o s i t i o n s 15, 16, 1 7 and 18 by t h e c a t a l y t i c r e d u c t i o n of dotriaconta-15, 17-diyne. This was obtained by o x i d a t i v e l y coupling hexadec-1-yne, i n
A method is described by which tritium-labeled alltrans retinoic acid of high specific activity (up to \(\sim 51\) \(\mathrm{Ci} / \mathrm{mmol}\) corresponding to \(85 \%\) of theoretical) is converted photolytically within a fraction of a second to a mixture of retinoic acid stereoisomers. One of
## Abstract The possibilities of tritium labelling of tofizopam (**1**) at high specific activity were investigated. Two methods, one by isotopic exchange, and one by catalysed halogenโtritium replacement were developed. The latter was found to be more rational, and **1** specifically labelled with
## Abstract Tritium labelled amitriptyline (__1__) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the oxoโgroup against reduction. It