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Tritium labelled compounds of high specific activity II. amitriptyline

✍ Scribed by G. Zólyomi; F. Sirokmán; G. Tóth; I. Elekes

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
374 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Tritium labelled amitriptyline (1) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the oxo‐group against reduction. It was demonstrated by degradation that isotope exchange occurred exclusively in specified position.

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