Synthesis of v e r a t r i d i n e labeled with tritium on t h e aromatic residue a t p o s i t i o n 5' i s described. F i r s t , a precursor bromoveratridine, 3-(5-bromoveratroyl) veracevine, was prepared which was converted i n t o t h e labeled v e r a t r i d i n e by cata l y t i c dehalogena
Synthesis of tritium-labelled imipramine and desipramine with high specific activities
β Scribed by L. A. Yakovleva; Ju. L. Kaminski; L. P. Sosnova; B. K. Kudelin
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 189 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
[Gβ^3^H]imipramine and [Gβ^3^H]desipramine with specific activities 110β160 and 80β100 kCi/mol, respectively were synthesized by high temperature solidβphase catalytic isotope exchange with gaseous tritium.
π SIMILAR VOLUMES
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The tobacco smoke p a r t i c u l a t e phase marker d o t r i a c o n t a n e was l a b e l l e d w i t h tritium a t p o s i t i o n s 15, 16, 1 7 and 18 by t h e c a t a l y t i c r e d u c t i o n of dotriaconta-15, 17-diyne. This was obtained by o x i d a t i v e l y coupling hexadec-1-yne, i n
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## Abstract The possibilities of tritium labelling of tofizopam (**1**) at high specific activity were investigated. Two methods, one by isotopic exchange, and one by catalysed halogenβtritium replacement were developed. The latter was found to be more rational, and **1** specifically labelled with