Convenient biological preparation of pure high specific activity 14C-labelled methane
β Scribed by Lacy Daniels; J. G. Zeikus
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 287 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Three major DDD isomers, O,P'-DDD, m,p'-DDD and p,p'-DDD, 14C-labelled in the para-chlorophenyl ring, have been synthesized. The DDD products were obtained in isotopic yields ranging fran 42% to 58% and were of high specific activities; 31 mCi/mmol (0,~'-DDD; m,p'-DDD) and 19,8 mCi/mmol (p,p'-DDD).
C-labeled methyl iodide is one of the most applicable precursors for the preparation of "C-labeled radiopharmaceuticals. the neuroleptic tracer with high specific activity for neurofunctional study in the brain, our effort was directed to the development of convenient production method of "C-labeled
Dz binding properties, i s described. The pyrrolidine moiety of the molecule i s labelled with tritium by hydrogenation, to a specific a c t i v i t y o f up to 58 Ci/mnol and subsequently reacted with an acid chloride. The specificity o f the label i s confirmed by 'H-"R.
## Abstract Tritiated hydrocarbons may be prepared by Kolbe electrolysis of carboxylic acids which have been labelled by catalytic exchange in tritiated water.