✦ LIBER ✦

Studies on methylazoxymethanol synthesis of 14C and 3H labelled methylazoxymethyl-acetate

✍ Scribed by Marc Horisberger; Hiromu Matsumoto

Publisher: John Wiley and Sons
Year: 1968
Tongue: French
Weight: 341 KB
Volume: 4
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590040210

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✦ Synopsis

The synthesis of and 3H labelled methylazoxymethylacetate, ( M A M -OAc) , a hepatotoxic and carcinogenic compound, was accomplished by the incorporation of a radioisotope labelled methyl group into N, N'-dimethylhydrazine with methyl iodide instead oj dimethyl sulfate. Monosodium dibenzoylhydrazine was methylated with labelled methyl iodide and the second methyl group was subsequently added with unlabelled dimethyl sulfate to produce N,N'dimethylhydrazine. This modiJication made it possible to prepare labelled N , N'-dimethylhydrazine with a small amount of total radioactivity and avoid an excessive waste of the methyl label. The labelled compound was then used in the synthesis of MAM-OAc by a previously published procedure. The incorporation of radioactivity into N,N'-dimethylhydrazine was in the range of 15-95 %.

Better yields were obtained ,for 3H than for I4C MAM-OAc.

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