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Economical syntheses of 3H-2H and 14C-labeled ethyl acetates

✍ Scribed by Francisco J. Alvarez; Ildiko M. Kovach; Richard L. Schowen

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
165 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Tritium and ^14^C‐labeled isomers of ethyl acetate are excellent substrates for competitive dual‐labeled radioactive isotopic measurements of β‐deuterium and β‐tritium isotope effects. Methods are given for preparation of the ethyl esters of acetic acid‐2‐^3^H, acetic acid‐2‐^14^C, and acetic acid‐2,2‐2H~2~‐2‐^3^H, and of the acetic acid ester of ethanol‐l‐^14^C from the least costly labeled precursors in high purity (yield 70‐80%) on the mmole scale.

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