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Syntheses of 14C and 3H labelled forms of donetidine - A histamine H2-antagonist

✍ Scribed by M A Armitage; M M Cashyap; D Saunders

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 440 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240410

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✦ Synopsis

Three syntheses o f r a d i o l a b e l l e d 2-[2-(2-N.N-Dlmethylarnlnomethyl-5 -f uranyl-methyl thlo)ethylamlno]-5-( 6-hydroxy-l-plcolyl ) -4pyrlmldone t r i h y d r o c h l o r l d e (donetldlne t r i h y d r o c h l o r i d e ) are described. One descrlbes the preparatlon o f the f r e e base, and two o f I t s t r l h y d r o c h l o r l d e . 1. A f i v e stage synthesis (Scheme 1) whlch gave ''C-donetldlne * To whom correspondence should be addressed. 0362-4803/87/040431-15sO7.50 @ 1987 by John Wiley & Sons, Ltd.

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