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Synthesis of 14C-labelled antitumor agents. II. A facile synthesis of ring-14C-labelled para-toluic acid as an intermediate for synthesis of ring-14C-labelled procarbazine

✍ Scribed by Ying-Tsung Lin; Robert J. Dummel; Morris A. Leaffer; Masato Tanabe

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
156 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

p‐Toluic acid‐ring‐^14^C was synthesized by the Friedel‐Crafts p‐carbamylation of toluene‐ring‐^14^C with N,N‐disubstituted carbamyl chloride and subsequent hydrolysis. The radiochemical yield was 61%. An attempt was made to apply this method for the synthesis of benzoic acid‐ring‐^14^C from benzene‐ring‐^14^C.

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