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Synthesis of 14C-labelled 4-hydroperoxyisophosphamide, an effective antitumor agent

✍ Scribed by T. Nagasaki; Y. Katsuyama; H. Minato

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
193 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

4‐Hydroperoxyisophosphamide (II), an effective antitumor agent has been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐6 position of the molecule to give (VII). The overall radiochemical yield was 4.4% based on barium carbonate‐^14^C. The labelled compound obtained was used for absorption and metabolism studies.

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