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Synthesis of [18-14C]octatriacontane from [1-14C]stearic acid

✍ Scribed by Saifunnissa B. Hassam

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
490 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

14

A method was developed to synthesize C-labelled n-qtkanes for use in cigarette smoke studies. Specifica],ly, n-[18-Cloctatriacontane was synthesized from 1 mCi [l-Clstearic acid in a radiochemical yield of 20%. synthesis were two consecutive alkylations yf tosylmethyl isocyanide followed by acid hydrolysis to [18-Cl-19-octatriacontanone and modified Wolff-Kishner reduction tolfhe n-alkane. After purification on silica gel 25 mg of 118-Cloctatriacontane was obtained with a total radioactivity of 200 uC1, a specific activity o f 4.3 mCi/mmol, and a radiochemical purity in excess of 98% by thin layer radiochromatography. The method has also been applied to the synthesis of unlabeled n-pentatriacontane and is considered to be generally applicable to the synthesis of radiolabeled alkanes from radiolabeled fatty acids.

[ 18-4C I octatri acontane, radiosynthesi s, C-1 abeled a1 kanes.

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