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Synthesis of [14C2] SDZ FOX 988, a hypoglycemic agent

✍ Scribed by Ustun B. Sunay; Kenrick Talbot; Kapa Prasad; George Lee; Lawrence Jones

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
268 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

4‐[2,2‐Dimethyl‐1‐oxopropyl‐1‐[^14^C]‐4‐[2,2‐dimethyl‐1‐oxopropyl‐ 1‐[^14^C]‐phenyl(methoxyimino)‐benzoic acid, methyl ester, [^14^C~2~] SDZ FOX 988, doubly labelled in the two keto carbons, was prepared from 4‐bromotoluene in four steps. The final condensation featured a novel method for preparation of N‐oxyimidic acid derivatives.

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