Microwave-assisted synthesis of (RS) methyl-2-([2′-14C]4,6-dimethoxypyrimidin-2′-yloxy)-2-phenyl [1-14C]ethanoate
✍ Scribed by K. M. Mathew; S. Ravi; V. K. P. Unny; N. Sivaprasad
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 121 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
We report here a facile synthesis of (RS) methyl-2-([2 0 -14 C]4,6-dimethoxypyrimidin-2 0yloxy)-2-phenyl [1-14 C]ethanoate under microwave irradiation.
📜 SIMILAR VOLUMES
## Abstract The syntheses of 4‐amino‐3,2′‐dimethyl‐biphenyl‐3‐methyl‐^14^C, a potent carcinogen and mutagen, and 4‐amino‐2′‐methylbiphenyl‐2′‐methyl‐^14^C, an analogue having weaker activity, are described. In both cases, label was introduced with Cu^14^ CN.
Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone
## Abstract Phenyl [1‐^14^C] acetylene (0.012mCi/mmole) was synthesized in 12.5% yield from [1‐^14^C] acetic acid through [1‐^14^C] acetophenone, its semicarbazone, and 4‐phenyl‐[4‐^14^C] 1,2,3‐selenadiazole obtained by selenium dioxide oxidation. Oxidative coupling gave 1,4‐diphenyl [1,4‐^14^C~2~]
## Abstract N‐Phenyl‐2‐naphthylamine has been synthesized (1) with ^14^C in positions 1, 4, 5 and 8, (2) with ^13^C in position 8 (small amounts of [1‐^13^C] naphthalene and 2‐[8‐^13^C]naphthylamine are formed as by‐products), and (3) with the N‐phenyl nucleus uniformly labelled with ^14^C.
## Abstract High specific activity ethanedial‐1,2‐^14^C~2~ has been prepared in 74% radiochemical yield by oxidation of paraldehyde‐^14^C~6~ with selenious acid. The crude ethanedial‐^14^C~2~ was directly condensed with 1, 2, 4‐benzenetriamine dihydrochloride in aqueous sodium carbonate giving 6‐qu