## Abstract [2‐^13^C, 2‐^14^C]2‐Aminoethanol hydrochloride was prepared in good yield from Na\*CN in a two step sequence by first converting the Na\*CN to OHCH~2~\*CN and then reducing the nitrile directly with a solution of borane‐tetrahydrofuran complex. The reaction procedure was simple and the
Synthesis of N-phenyl-2-[1,4,5,8-14C]naphthylamine, N-phenyl-2-[8-13C] naphthylamine, and N-[U-14C]phenyl-2-naphthylamine
✍ Scribed by G H Walker; D E Hathway
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 287 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
N‐Phenyl‐2‐naphthylamine has been synthesized (1) with ^14^C in positions 1, 4, 5 and 8, (2) with ^13^C in position 8 (small amounts of [1‐^13^C] naphthalene and 2‐[8‐^13^C]naphthylamine are formed as by‐products), and (3) with the N‐phenyl nucleus uniformly labelled with ^14^C.
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## N-[N-[(S)-1-Ethoxycarbonyl -3-phenylpropyll-La l a ~y l ~-E -T i n d a n -2 -y 1 ) glycine hydrochloride (CV-3317) , a new potent angiotensin converting enz e inhibitor, was labeled with carbon-14. Diethyl [U-'C]oxalate was condensed with ethyl 3-phenylpropionate, subsequently decarboxylated to
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