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Synthesis of [2-13C, 2-14C]2-aminoethanol, [1-13C, 1-14C]2-chloroethylamine, N,N′-bis([1-13C, 1-14C]2-chloroethyl)-N-nitrosourea(BCNU) and N-([1-13C, 1-14C]2-chloroethyl)-N-nitrosourea(CNU)

✍ Scribed by Ramani Narayan; Ching-Jer Chang

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
311 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[2‐^13^C, 2‐^14^C]2‐Aminoethanol hydrochloride was prepared in good yield from Na*CN in a two step sequence by first converting the Na*CN to OHCH~2~*CN and then reducing the nitrile directly with a solution of borane‐tetrahydrofuran complex. The reaction procedure was simple and the pure product could be obtained readily. Using this specifically labelled precursor, the synthesis of [1‐^13^C, 1‐^14^C]2‐chloroethylamine hydrochloride, N‐([1‐^13^C, 1‐^14^C]2‐chloroethyl)‐N‐nitrosourea(CNU) and N,N′‐bis([1‐^13^C, 1‐^14^C]2‐chloroethyl)‐N‐nitrosourea(BCNU) in good yield without isotope scrambling was also reported.

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