𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A concise synthesis of [carbonyl-11C]melatonin and N-[carbonyl- 11C]acetylserotonin

✍ Scribed by Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Hiroshi Sugiyama; Hiromu Takahashi; Akira Wakui; Hiroshi Fukuda; Kazuo Kubota; Yoshinao Abe; Tatsuo Yamaguchi; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
218 KB
Volume
29
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Rapid chemical syntheses of [carbonyl‐ ^11^C]melatonin and N‐[carbonyl‐ ^11^C]acetylserotonin starting from [^11^C]carbon dioxide are described. The radiochemical yield (based on [carbonyl‐^11^C]‐acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.

📜 SIMILAR VOLUMES

Enzymatic synthesis of [11C]N-acetylsero
Enzymatic synthesis of [11C]N-acetylserotonin
✍ Geert Mannens; Guido Slegers; Patrick Goethals 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 294 KB 👁 1 views

## Abstract An enzymatic synthesis of [^11^C] __N__‐acetylserotonin is described. [1‐^11^C] acetate is produced by reacting ^11^CO~2~ with methylmagnesium bromide and converted to [^11^C]acetylCoA by passage over a first enzyme reactor containing immobilized acetylcoenzyme A synthetase. The produce

Synthesis of [11C-carbonyl]hydroxyureas
Synthesis of [11C-carbonyl]hydroxyureas by a rhodium-mediated carbonylation reaction using [11C]carbon monoxide
✍ Julien Barletta; Farhad Karimi; Bengt Långström 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 107 KB

11 C]Hydroxyurea has been successfully labelled using [ 11 C]carbon monoxide at low concentration. The decay-corrected radiochemical yield was 38 AE 3%, and the trapping efficiency of [ 11 C]carbon monoxide in the order of 90 AE 5%. This synthesis was performed by a rhodium-mediated carbonylation

An efficient synthesis of 2- [ carbonyl-
An efficient synthesis of 2- [ carbonyl- 11C]acetamido-2-deoxy-D-glucopyranose (N-[carbonyl-11C]acetyl-D-glucosamine)
✍ Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Hiroshi Sugiyama; Kazuo Ku 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 203 KB

## Abstract A rapid chemical synthesis of 2‐[__carbonyl‐^11^C__]acetamido‐2‐deoxy‐D‐glucopyranose (__N__‐[__carbonyl__‐^11^C]acetyl‐D‐glucosamine) starting from [^11^C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are

Synthesis of N-(2,5-dimethoxybenzyl)-N-(
Synthesis of N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)[carbonyl-11C]acetamide ([carbonyl-11C]DAA1106) and analogues using [11C]carbon monoxide and palladium(0) complex
✍ Obaidur Rahman; Bengt Långström 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 137 KB

## Abstract __N__‐(2,5‐Dimethoxybenzyl)‐__N__‐(5‐fluoro‐2‐phenoxyphenyl)acetamide (DAA1106), a potent and selective ligand for peripheral benzodiazepine receptor, and eight structurally related analogues were labelled with ^11^C at the carbonyl position using a low concentration of [^11^C]carbon mo

A simple one-pot synthesis of cyclopropa
A simple one-pot synthesis of cyclopropane [11C]carbonyl chloride. Synthesis and biodistribution of [11C]cyclorphan
✍ Daniel W. McPherson; Dah-Ren Hwang; Joanna S. Fowler; Alfred P. Wolf; Robert M. 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 353 KB

N a t i o n a l Laboratory, Upton, NY 11973 Received Sumary A r a p i d , one-pot, s y n t h e s i s of cyclopropane [ llC]carbonyl c h l o r i d e was developed. This s y n t h e s i s proceeded i n 807; r a d i ochemical y i e l d (EOB) i n a s y n t h e s i s time of LO minutes. This a c i d c h