✦ LIBER ✦

Synthesis of 11C-pindolol

✍ Scribed by C. Prenant; J. Sastre; C. Crouzel; A. Syrota

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 158 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240212

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✦ Synopsis

A method is described by which 100 mCi of pindolol may be obtained from about 1.5 Ci l1CO2 in 30 minutes. The product is chromatographically pure, sterile and apyrogenic with a specific activity between 600 and 1000 mCi/piuole at the time of use.

The synthesis involves the preparation of lh-acetone followed by fixation of the isopropyl group on the precursor : 2 hydroxy-3 ( 4indolyoxy) propylamine by formation of an imine, the reduction of the latter by sodium cyanoborohydride.

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