𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of racemic [α-11C]amphetamine and [α-11C]phenethylamine from [11C]nitroalkanes

✍ Scribed by Karl-Olof Schoeps; Christer Halldin

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
391 KB
Volume
31
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of racemic [α‐^11^C]amphetamine and [α‐^11^C]‐phenethylamine from on‐line produced [^11^C]nitroethane and [^11^C]nitromethane, respectively, is described. The condensations of nocarrier‐added [^11^C]nitroalkanes with benzaldehyde to form [β‐^11^C]β‐nitrostyrenes were investigated under basic and acidic conditions. The [β‐^11^C]β‐nitrostyrenes were reduced with lithium aluminium hydride to produce the corresponding saturated amines. Purification was performed with semi‐preparative reversed‐phase HPLC using a Suplex pKb‐100 column. The total radiochemical yields were 7‐20% (from EOB and decaycorrected) and 24‐35% (based on [^11^C]nitroalkanes and decay‐corrected) with a total synthesis time of 40‐55 min. The specific radioactivity of [α‐^11^C]amphetamine and [α‐^11^C]phenethylamine at EOS was 200‐1000 Ci/mmol (7.4‐37 GBq/μmol) with a radiochemical purity >99%.

📜 SIMILAR VOLUMES

Synthesis of racemic [2-11C]phenylglycin
Synthesis of racemic [2-11C]phenylglycine
✍ Christer Halldin; Bengt Långström 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 331 KB

## Abstract The synthesis of racemic [2‐^11^C]phenylglycine, starting with ^11^CO~2′~ is reported. The [^11^C]benzaldehyde, prepared as previsously described in a two‐step reaction from the corresponding [^11^C]benzoic acid salt, was used in a modified Bücherer‐Strecker reaction. The radiochemical

Synthesis of carbon-11 labeled methylcar
Synthesis of carbon-11 labeled methylcarbamates from [11C]-methylchloroformate
✍ Hayden T. Ravert; William B. Mathews; John L. Musachio; Robert F. Dannals 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 386 KB

1 1C]-Methylchloroformate, a novel [ 1 lcl-acylating agent, was generated in situ from [11C]-methanol and phosgene. To explore the utility of [11C]-methylchloroformate, this agent was reacted with several amines to yield their corresponding [I 1C]-labeled methylcarbamates. The average synthesis (inc

Synthesis of [1-11C]propyl and [1-11C]bu
Synthesis of [1-11C]propyl and [1-11C]butyl iodide from [11C]carbon monoxide and their use in alkylation reactions
✍ Jonas Eriksson; Gunnar Antoni; Bengt Långström 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB

## Abstract A method to prepare [1‐^11^C]propyl iodide and [1‐^11^C]butyl iodide from [^11^C]carbon monoxide via a three step reaction sequence is presented. Palladium mediated formylation of ethene with [^11^C]carbon monoxide and hydrogen gave [1‐^11^C]propionaldehyde and [1‐^11^C]propionic acid.

N.C.A. 11C-labelling of benzenoid compou
N.C.A. 11C-labelling of benzenoid compounds in ring positions: Synthesis of nitro-[1-11C]benzene and [1-11C]aniline
✍ J. Steinbach; P. Mäding; F. Füchtner; B. Johannsen 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 400 KB

The paper describes the first method for n.c.a. "C-ring labelling of benzenoid compounds having a reactive group for further derivatization by use of the known principle of synchronous six-electron cyclization of hexatriene systems into aromatics. Nitro-["Clmethane (1) prepared from cyclotron-produc