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Synthesis of racemic [2-11C]phenylglycine

✍ Scribed by Christer Halldin; Bengt Långström

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
331 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of racemic [2‐^11^C]phenylglycine, starting with ^11^CO~2′~ is reported. The [^11^C]benzaldehyde, prepared as previsously described in a two‐step reaction from the corresponding [^11^C]benzoic acid salt, was used in a modified Bücherer‐Strecker reaction. The radiochemical yield of [2‐^11^C]phenylglycine in benzaldehyde‐added experiments was 20 %, and in non‐added experiments 6 % (corrected for decay). The overall synthesis time, starting with ^11^CO~2~, was 50 min (including LC separation). The radiochemical purity was higher than 99 %.

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