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Synthesis of racemic [2′-13C]tryptophan

✍ Scribed by B. R. Branchini; F. G. Prendergast; G. A. Spencer; J. D. Hugdahl; B. D. Ray; M. D. Kemple

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 310 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240605

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✦ Synopsis

2-l3C] Indole was synthesized in 39% yield by a three-step procedure starting with K13CN. The labeled indole was converted to D,L[2'-13d tryptophan in three subsequent steps and the overall yield from K13CN was 13.5%. Proton and 13C-NMR, and GC/mass spectral analyses confirmed the position and extent of 13C incorporation.

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