Synthesis and α1-Antagonist Activity of New Prazosin-and Benextramine-Related Tetraamine Disulfides. -The title compounds of type (I), prepared by standard procedures, display marked selectivity at α1-adrenoceptors. In contrast to prazosin and benextramine (I) shows an 11-fold selectivity for α 1B-a
Synthesis of 11C-labelled prazosin, an α — 1 adrenoreceptor antagonist
✍ Scribed by Mirko Diksic; Dean Jolly
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 80 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The ^11^C‐labelling of the taxane derivative BAY 59‐8862 (**1**), a potent anticancer drug, was carried out as a module‐assisted automated multi‐step synthesis procedure. The radiotracer **[^11^C]1** was synthesized by reacting [1‐^11^C]acetyl chloride (**6**) with the lithium salt of t
The paper describes the first method for n.c.a. "C-ring labelling of benzenoid compounds having a reactive group for further derivatization by use of the known principle of synchronous six-electron cyclization of hexatriene systems into aromatics. Nitro-["Clmethane (1) prepared from cyclotron-produc
## Abstract Microbial conversion of deuterium‐labelled TAK‐637 ((__aR,9S__)‐[10,10,11, 11‐^2^H~4~]‐7‐[3,5‐__bis__(trifluoromethyl)benzyl]‐8,9,10,11‐tetrahydro‐9‐methyl‐5‐(4‐methylphenyl)‐__7H__‐[1,4]diazocino[2,1‐__g__][1,7]naphthyridine‐6,13‐dione, **1**) was carried out using __Streptomyces subru
## Abstract Efficient carbon‐14 labeling of four potent and selective DP1 antagonists is reported. The synthetic sequence began with α‐hydroxylation, reduction of an ester, followed by oxidative diol cleavage and aldehyde reduction. The resulting alcohol **4** was converted to a mesylate then nucle