𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 11C-labelled prazosin, an α — 1 adrenoreceptor antagonist

✍ Scribed by Mirko Diksic; Dean Jolly


Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
80 KB
Volume
26
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


ChemInform Abstract: Synthesis and α1-An
✍ D. GIARDINA; M. CRUCIANELLI; U. GULINI; G. MARUCCI; C. MELCHIORRE; S. SPAMPINATO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

Synthesis and α1-Antagonist Activity of New Prazosin-and Benextramine-Related Tetraamine Disulfides. -The title compounds of type (I), prepared by standard procedures, display marked selectivity at α1-adrenoceptors. In contrast to prazosin and benextramine (I) shows an 11-fold selectivity for α 1B-a

Synthesis of a 11C-labelled taxane deriv
✍ P. Mäding; J. Zessin; U. Pleiß; F. Füchtner; F. Wüst 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 173 KB

## Abstract The ^11^C‐labelling of the taxane derivative BAY 59‐8862 (**1**), a potent anticancer drug, was carried out as a module‐assisted automated multi‐step synthesis procedure. The radiotracer **[^11^C]1** was synthesized by reacting [1‐^11^C]acetyl chloride (**6**) with the lithium salt of t

N.C.A. 11C-labelling of benzenoid compou
✍ J. Steinbach; P. Mäding; F. Füchtner; B. Johannsen 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 400 KB

The paper describes the first method for n.c.a. "C-ring labelling of benzenoid compounds having a reactive group for further derivatization by use of the known principle of synchronous six-electron cyclization of hexatriene systems into aromatics. Nitro-["Clmethane (1) prepared from cyclotron-produc

Microbial synthesis of a deuterium-label
✍ Naoki Tarui; Yoshinori Ikeura; Hideaki Natsugari; Kazuo Nakahama 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB

## Abstract Microbial conversion of deuterium‐labelled TAK‐637 ((__aR,9S__)‐[10,10,11, 11‐^2^H~4~]‐7‐[3,5‐__bis__(trifluoromethyl)benzyl]‐8,9,10,11‐tetrahydro‐9‐methyl‐5‐(4‐methylphenyl)‐__7H__‐[1,4]diazocino[2,1‐__g__][1,7]naphthyridine‐6,13‐dione, **1**) was carried out using __Streptomyces subru

Practical [14C]-synthesis of molecules c
✍ Carl Berthelette; Zhaoyin Wang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 104 KB

## Abstract Efficient carbon‐14 labeling of four potent and selective DP1 antagonists is reported. The synthetic sequence began with α‐hydroxylation, reduction of an ester, followed by oxidative diol cleavage and aldehyde reduction. The resulting alcohol **4** was converted to a mesylate then nucle