𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637

✍ Scribed by Naoki Tarui; Yoshinori Ikeura; Hideaki Natsugari; Kazuo Nakahama

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
95 KB
Volume
44
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Microbial conversion of deuterium‐labelled TAK‐637 ((aR,9S)‐[10,10,11, 11‐^2^H~4~]‐7‐[3,5‐bis(trifluoromethyl)benzyl]‐8,9,10,11‐tetrahydro‐9‐methyl‐5‐(4‐methylphenyl)‐7H‐[1,4]diazocino[2,1‐g][1,7]naphthyridine‐6,13‐dione, 1) was carried out using Streptomyces subrutilus IFO13388 to give a deuterium‐labelled hydroxylated TAK‐637 ((aR,9S)‐ [10,10,11,11‐^2^H~4~]‐7‐[3,5‐bis(trifluoromethyl)benzyl]‐8,9,10,11‐tetrahydro‐9‐methyl‐5‐(4‐hydroxymethylphenyl)‐7H‐[1,4]diazocino[2,1‐g][1,7]naphthyridine‐6,13‐dione, 2) for use as an internal standard in LC‐MS studies. Copyright © 2001 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

ChemInform Abstract: Efficient Synthesis
ChemInform Abstract: Efficient Synthesis of (1R)-[3,5-Bis(trifluoromethyl)phenyl] Ethanol, a Key Intermediate for Aprepitant, an NK-1 Receptor Antagonist.
✍ Pravinchandra J. Vankawala; Naveenkumar Kolla; Chandrashekar R. Elati; M. Sreeni 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v