Synthesis of [2H, 13C] and [14C] labeled vasopressin V1a/V2 receptor antagonist RWJ-676070 and its stable labeled N-des-benzoyl metabolite

Synthesis of 13C, 14C and 2H13C labeled

Synthesis of 13C, 14C and 2H13C labeled adrenoceptor antagonists: 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride and its N-desmethyl analog

✍ A. J. Villani; F. Etzkorn; G. A. Rotert; J. R. Heys 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 428 KB 👁 1 views

The compound 6-chloro-2,3,4,5-tetrahydroi~-methyl-l &3-t#nzazepine (SK&F 86466) was prepared in phenyl-U-C and phenyl-C , labeled forms in a six step sequence beginning with the appropriately labeled benzenes. In addition, the N-desmeJhyl analog of the carbon-1 4 labeled isotopomer and the N-methyl-