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Synthesis of 13C, 14C and 2H13C labeled adrenoceptor antagonists: 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride and its N-desmethyl analog

✍ Scribed by A. J. Villani; F. Etzkorn; G. A. Rotert; J. R. Heys

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
428 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The compound 6-chloro-2,3,4,5-tetrahydroi~-methyl-l &3-t#nzazepine (SK&F 86466) was prepared in phenyl-U-C and phenyl-C , labeled forms in a six step sequence beginning with the appropriately labeled benzenes. In addition, the N-desmeJhyl analog of the carbon-1 4 labeled isotopomer and the N-methyl-H derivative of the carbon-I3 isotopomer were prepared via the N-(2,2?&trichloroethyl) carbamates by hydrolysis and lithium aluminum deuteride reduction, respectively. reylyvo r d s: ( H, C)benzazepine, ( C,)benzene, [U-Clbenzene. (.' 3 C ] p e n z a z e p i n yd [ ' 4 C ] b e n z a z e p i n 8 ,

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