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ChemInform Abstract: Efficient Synthesis of (1R)-[3,5-Bis(trifluoromethyl)phenyl] Ethanol, a Key Intermediate for Aprepitant, an NK-1 Receptor Antagonist.

✍ Scribed by Pravinchandra J. Vankawala; Naveenkumar Kolla; Chandrashekar R. Elati; M. Sreenivasulu; K. Arun Kumar; Yerrimilli Anjaneyulu; Sundaram Venkatraman; Apurba Bhattacharya; Vijayavitthal T. Mathad


Publisher
John Wiley and Sons
Year
2008
Weight
29 KB
Volume
39
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Synthetic Studies on Sphingolipids. Part 4. Improved Synthesis of (4S)-4-[(1S,2R)-1,2-Epoxybut-3-enyl]-2-phenyl-2-oxazoline, a Key Intermediate for Sphingolipids. -A novel route to the title compound (VIII) is reported with an oxidative bromination [(VI) β†’ (VII)] as the key step.